SCIENTIFIC PUBLICATIONS


Latest Publications & Studies

Healing of Chronic Wounds by Copper Oxide-Impregnated
Novel antimicrobial wound dressings impregnated with copper oxide micro-particles have been cleared for treatment of acute and chronic wounds.
Authors: Eyal Melamed, Patrick Kiambi, Dancan Okoth, Irena Honigber
Read more >>

Copper, an Abandoned Player Returning to the Wound Healing Battle
Copper has two key properties that endow it as an excellent active ingredient to be used in the “wound healing battle”. Both gram-positive and gramnegative bacteria, including antibiotic resistant bacteria and hard to kill bacterial spores, fungi and viruses, when exposed to high copper concentrations, are killed.
Authors: Gadi Borkow PhD, Eyal Melamed
Read more >>

scientific journals

Copper-oxide impregnated respiratory masks may significantly reduce the risk of SARS-CoV-2 cross-contamination
N95s and regular surgical masks were produced in which the external layers were made with nonwoven fabric impregnated with copper-oxide microparticles. The masks reduced the infectious titers of SARS-CoV-2 by more than 99.9% within 1 minute of contact, as determined by TCID50 assay and serial PCR assays. The use of masks capable of rendering the SARS-CoV-2 non-infectious within minutes, may significantly reduce the risk of viral transmission and infection.
Authors: Gadi Borkow PhD, Danny Lustiger, Eyal Melamed, Vicki Herrera
Read more >>

Safety of Using Copper Oxide in Medical Devices and Consumer Products
Copper has two key properties that make it an active ingredient in the medical devices currently being developed. First, copper is an essential trace element needed by humans, which plays a key role in many physiological processes in different tissues. For example, copper has been shown to be involved in angiogenesis and in wound healing. Second, copper has very potent antibacterial, antifungal, antiviral, and acaricidal properties.
Authors: Gadi Borkow
Read more >>

Using Copper to Fight Microorganisms
The manuscript reviews the biocidal mechanisms of copper and its current uses in the fight against transmission of health-associated (nosocomial) pathogens, foodborne diseases, dust mites loads and fungal and wound infections. The manuscript also discusses possible future applications such as filtration devices capable of deactivating contaminated blood products and breastmilk.
Authors: Gadi Borkow
Read more >>

A Novel Anti-Influenza Copper Oxide Containing Respiratory Face Mask
Protective respiratory face masks protect the nose and mouth of the wearer from vapor drops carrying viruses or other infectious pathogens.
Authors: Gadi Borkow, PhD, Steve S. Zhou,Tom Page, Jeffrey Gabbay
Read more >>

Neutralizing Viruses in Suspensions by Copper Oxide-Based Filters
Viral transmission through contaminated liquids, such as blood and breast milk, represents an enormous threat to populations worldwide.
Authors: Gadi Borkow, PhD, Robert W. Sidwell, Donald F. Smee, Dale L. Barnard
Read more >>

Copper Oxide Impregnated Wound Dressing: Biocidal and Safety Studies
Copper plays a key role in angiogenesis and in the expression and stabilization of extracellular skin proteins. Copper also exhibits broad biocidal properties.
Authors: Gadi Borkow, PhD; Neta Okon-Levy, PhD; Jeffrey Gabbay
Read more >>

Copper, an Ancient Remedy Returning to Fight Microbial, Fungal and Viral Infections
Copper has potent biocidal properties. Copper ions, either alone or in copper complexes, have been used for centuries to disinfect liquids, solids and human tissue.
Authors: Gadi Borkow PhD, J. Gabbay
Read more >>

Fighting nosocomial infections with biocidal non-intrusive hard and soft surfaces
A nosocomial, or hospital-acquired, infection is a new infection that develops in a patient during hospitalization.
Authors: Gadi Borkow PhD, Alastair Monk
Read more >>

Deactivation of Human Immunodeficiency Virus Type 1 in Medium by Copper Oxide-Containing Filters
Human immunodeficiency virus type 1 (HIV-1) can be transmitted through breast-feeding and through contaminated blood donations. Copper has potent biocidal properties and has been found to inactivate HIV-1 infectivity.
Authors: Gadi Borkow PhD, Humberto H. Lara, Chandice Y. Covington
Read more >>

Stability of SARS-CoV-2 in different environmental conditions
This virus can be detected on different surfaces in a contaminated site. Here, we report the stability of SARS-CoV-2 in different environmental conditions.
Authors: Alex W H Chin, Julie T S Chu, Mahen R A Perera
Read more >>

Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials
The evolution of new and reemerging historic virulent strains of respiratory viruses from animal reservoirs is a significant threat to human health. Inefficient human-to-human transmission of zoonotic strains may initially limit the spread of transmission, but an infection may be contracted by touching contaminated surfaces
Authors: Sarah L. Warnes, Zoë R. Little, C. William Keevil
Read more >>

Antimicrobial Copper Touch Surfaces
Reduce Infections, Liberate Resources And Cut Costs There are many technologies and materials on the market, but none are as effective under typical indoor conditions as copper, and its hygienic properties are far from new to us.
Authors: Angela Vessey
Read more >>

Neutralizing Viruses in Suspensions by Copper Oxide-Based Filters
We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media.
Authors: Gadi Borkow PhD, Robert W. Sidwell, Donald F.
Read more >>

Putting copper into action: copper‐impregnated products with potent biocidal activities
This study demonstrates the broad‐spectrum antimicrobial (antibacterial, antiviral, antifungal) and antimite activities of copper‐impregnated fibers and polyester products. This technology enabled the production of antiviral gloves and filters (which deactivate HIV‐1 and other viruses), antibacterial self‐sterilizing fabrics (which kill antibiotic‐resistant bacteria.
Authors: Gadi Borkow PhD, J. Gabbay
Read more >>


studies in cosmetology

Improvement of Facial Skin Characteristics Using Copper Oxide
Copper plays a key role in several processes of skin formation and regeneration. Copper has been shown to be absorbed through intact skin. We hypothesized that sleeping on fabrics containing copper‐impregnated fibres would have a positive cosmetic effect on the skin. 
Authors: Gadi Borkow PhD, J. Gabbay, A. Lyakhovitsky, M. Huszar
Read more >>

Facial Skin Lifting and Brightening Following Sleep on Copper Oxide Containing Pillowcases
Copper plays a key role in many of the physiological processes that occur in the skin. Previously it was found that sleeping on pillowcases impregnated with microscopic copper oxide particles results in reduction of wrinkles and fine lines.
Authors: Gadi Borkow PhD, Adriana del Carmen Elias
Read more >>

Using Copper to Improve the Well-Being of the Skin
Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body.
Authors: Gadi Borkow PhD
Read more >>

Resolution of Skin Maladies of the Trapped Chilean Miners:
The Unplanned Underground Copper-Impregnated Antifungal Socks “Trial”
Authors: Gadi Borkow PhD, Juan Carlos Mellibovsky MD
Read more >>

Reduction of Facial Wrinkles Depth
Reduction of facial wrinkles depth by sleeping on copper oxide-containing pillowcases: a double blind, placebo controlled, parallel, randomized clinical study.
Authors: Ji Hwoon Baek PhD, Mi Ae Yoo BA, Jae Sook Koh PhD, Gadi Borkow PhD
Read more >>

Increased pro‐collagen 1, elastin, and TGF‐β1 expression by copper ions in an ex‐vivo human skin model
Clinical studies demonstrated that continued exposure to copper oxide–embedded textiles, such as pillowcases, significantly reduces depth of facial wrinkles and skin sagging and enhances skin elasticity.
Authors: Navit Ogen‐Shtern PhD, Katerina Chumin BSc, Guy Cohen PhD, Gadi Borkow PhD
Read more >>

foot health studies

Treatment of tinea pedis with socks containing copper-oxide impregnated fibers
Tinea pedis, known as Athlete’s foot, is a common fungal infection of the feet, the majority of cases caused by dermatophytes. Copper oxide has potent antimicrobial and antifungal properties.
Authors: Gadi Borkow PhD, Richard C. Zatcoff, Michael S. Smith
Read more >>

Reducing the risk of skin pathologies in diabetics by using copper impregnated socks
Diabetic individuals frequently suffer from skin pathologies, especially in their feet. Co-existing peripheral vascular disease and neuropathy exacerbate the capacity of these individuals to cope with infections, minor cuts and wounds, often leading to hard to treat and chronic ulcers.
Authors: Gadi Borkow PhD, Richard C. Zatcoff, Jeffrey Gabbay
Read more >>

Increase in skin surface elasticity in normal volunteer subjects following the use of copper oxide impregnated socks
Using copper oxide containing socks results in
an increase in skin elasticity of the feet.
Authors: P. Dykes
Read more >>

Improvement to Foot and Skin Appearance by Using Copper Oxide Impregnated
Copper has two key properties that make it an attractive component to introduce into textiles and socks in particular – it has potent biocidal properties and is an essential trace element vital for the normal function of skin.
Authors: Gadi Borkow PhD, Vikram Kanmukhla, Alastair B Monk
Read more >>

Analysis of the Effect of Wearing Copper Oxide Impregnated Socks on Tinea Pedis Based on “Before and After” Pictures – A Statistical Follow-up Tool
The present study demonstrates that statistical analysis of quantitative data obtained from digital images taken during treatment of tinea pedis is feasible and may serve as a tool for podiatrists in monitoring treatment.
Authors: Gadi Borkow PhD, Myriam Edith Gargiulo, Adriana del Carmen Elías
Read more >>

Protection of Soldiers’ Feet by Copper Oxide
Impregnated Socks

Soldiers’ fungal and bacterial infections, especially in their feet, cause significant reduction in their performance. Copper has potent antifungal and antibacterial properties.
Authors: Gadi Borkow PhD
Read more >>

Resolution of Skin Maladies of the Trapped Chilean Miners:
The Unplanned Underground Copper-Impregnated Antifungal Socks “Trial”
Authors: Gadi Borkow PhD, Juan Carlos Mellibovsky MD
Read more >>